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Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
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Published on: October 27, 2009

A quick simple method of determining platelet aggregability following glycoprotein IIb/IIIa receptor inhibitor

M Poullis1

  • 1Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK. mpoullis@rpms.ac.uk

Cardiology
|October 12, 1999
PubMed

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...