Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Persistent changes in the immune system 4-10 years after ABMT.

T Nordøy¹, A Kolstad, P Endresen

¹Department of Oncology, University Hospital of Tromsoe, Tromsoe, Norway.

Bone Marrow Transplantation

|October 12, 1999

Summary

Long-term immune changes persist years after autologous bone marrow transplantation (ABMT) for lymphoma. Patients show altered B and T cell counts, with a skewed CD4+ T cell response favoring Th2 immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gene expression and copy number profiling of follicular lymphoma biopsies from patients treated with first-line rituximab without chemotherapy.

Leukemia & lymphoma·2023

Same author

Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma.

Blood cancer journal·2017

Same author

Diffusing capacity impairment is prevalent in long-term lymphoma survivors after high-dose therapy with autologous stem cell transplantation.

Bone marrow transplantation·2016

Same author

Plasma immunoprofiling of patients with high-risk diffuse large B-cell lymphoma: a Nordic Lymphoma Group study.

Blood cancer journal·2016

Same author

Benzylpenicillin plus an aminoglycoside versus meropenem in neutropenic lymphoma and leukaemia patients with a suspected bacterial infection: a randomized, controlled trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016

Same author

Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation.

Acta oncologica (Stockholm, Sweden)·2016

Area of Science:

Immunology
Hematology
Oncology

Background:

Autologous bone marrow transplantation (ABMT) is a treatment for malignant lymphoma.
Early immune system changes are observed post-ABMT.
The long-term persistence of these immune alterations is not well understood.

Purpose of the Study:

To investigate the long-term persistence of immune system changes after ABMT in lymphoma patients.
To analyze specific immune cell subsets, including B cells, T cells (CD4+, CD8+), and their phenotypes (CD45RA, CD45RO).
To assess the functional immune response, specifically Th1/Th2 differentiation, years after ABMT.

Main Methods:

Study included 36 lymphoma patients who achieved complete remission (CR) after ABMT.
Median follow-up time was 5 years (range 4-10 years) post-ABMT.

Related Experiment Videos

Immunophenotyping and functional assays (cytokine production) were used to compare patients with healthy controls.

Main Results:

Patients exhibited increased B cell counts and decreased T cell counts compared to controls.
A significant reduction in CD4+ T cells and lower CD4/CD8 ratios were observed.
A shift towards a 'memory' T cell phenotype (CD45RO+) and a dominant Th2 response (higher IL-4 production) were noted, persisting years after treatment.

Conclusions:

Immune system alterations, including decreased CD4+ T cells and an imbalance in naive/memory T cell subsets, persist 4-10 years post-ABMT.
The functional immune response shows a persistent skew towards Th2 immunity.
These findings highlight the long-lasting impact of ABMT on immune reconstitution in lymphoma survivors.