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Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans
Published on: February 27, 2018
Disseminated infection due to Nocardia transvalensis coincident with Cryptococcus neoformans variety gattii
J R Dyer1, N Ketheesan, R E Norton
1Infectious Diseases Unit, St. Andrew's Hospital, Ipswich, Queensland, Australia. jdyer@medeserv.com.au
Abstract:
A case of meningitis due to Cryptococcus neoformans var. gattii coincident with disseminated Nocardia transvalensis infection is reported. Nocardia infection initially progressed despite high-dose antimicrobial therapy. Although a specific immunologic defect could not be defined, in vitro lymphocyte proliferation in response to stimulation with the Nocardia isolate was reduced. It is proposed that coinfection with Cryptococcus neoformans may have contributed to the observed impairment of lymphocyte function, leading to disseminated Nocardia disease and a suboptimal treatment response.
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