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Related Experiment Videos

Whither goest the RGS proteins?

D P Siderovski1, B Strockbine, C I Behe

  • 1Department of Pharmacology, School of Medicine, The University of North Carolina at Chapel Hill, 27599-7365, USA.

Critical Reviews in Biochemistry and Molecular Biology
|October 12, 1999
PubMed
Summary

Regulators of G protein signaling (RGS) proteins are now understood as multifaceted regulators of signal transduction, not just desensitizing agents. This review examines diverse RGS proteins and their complex roles.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Signaling

Background:

  • G protein-coupled signal transduction is crucial for cellular communication.
  • Desensitization mechanisms are key to regulating these pathways.
  • Regulator of G protein signaling (RGS) proteins were initially identified for their role in desensitization.

Purpose of the Study:

  • To review the documented and potential functions of various RGS proteins.
  • To explore the evolving understanding of RGS proteins beyond desensitization.
  • To highlight the multidomain compositions and multifocal roles of RGS proteins.

Main Methods:

  • Literature review of studies on RGS protein functions.
  • Analysis of documented and potential roles of specific RGS protein family members.
  • Consideration of RGS proteins with multidomain compositions.

Main Results:

  • RGS proteins exhibit diverse structures and functions.
  • Several RGS proteins possess multidomain compositions, indicating complex roles.
  • Examples include p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, GRKs, and the RGS6/7/9/11 subfamily.

Conclusions:

  • The appreciation of RGS proteins has shifted from simple desensitizing agents to complex signal transduction regulators.
  • RGS proteins play multifocal roles in cellular signaling pathways.
  • Understanding the diverse functions of RGS proteins is critical for deciphering cellular communication.

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