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Studies of hydroxypropyl methylcellulose donut-shaped tablets
1Zhongkun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China. chengkun99@usa.net
Drug Development and Industrial Pharmacy
|October 13, 1999
Summary
Tablet design significantly impacts drug release kinetics. Increasing hole size and number in donut-shaped tablets enhances zero-order drug release duration, while higher drug solubility shortens it.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Controlled drug release is crucial for therapeutic efficacy.
- Tablet geometry influences drug dissolution and release profiles.
Purpose of the Study:
- To investigate in vitro drug release from donut-shaped and multihole tablets.
- To evaluate the impact of tablet design parameters on drug release kinetics.
Main Methods:
- Preparation of simple uncoated compressed tablets with central or multiple holes.
- In vitro drug release studies using theophylline and diltiazem hydrochloride as model drugs.
- Analysis of drug release kinetics under varying hole sizes, number of holes, drug solubility, and stirring rates.
Main Results:
- Donut-shaped tablets achieved 80-90% zero-order drug release.
- Increased hole size and number of holes prolonged linear drug release duration.
- Higher drug solubility decreased the duration of linear drug release.
- Stirring rate had minimal effect on drug release.
Conclusions:
- Tablet geometry, specifically hole size and number, are key factors in achieving prolonged zero-order drug release.
- Drug solubility influences the linearity and duration of drug release from these tablet designs.
- Hollow tablet designs offer a promising approach for controlled drug delivery applications.