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Long-range charge hopping in DNA.

M Bixon1, B Giese, S Wessely

  • 1School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

Proceedings of the National Academy of Sciences of the United States of America
|October 16, 1999
PubMed
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Charge migration in DNA is key for molecular electronics. Guanine facilitates hole hopping, with transport limited by distance and intervening base pairs.

Area of Science:

  • Molecular Biology
  • Biophysics
  • Materials Science

Background:

  • Understanding charge migration in DNA is crucial for advancing molecular electronics and electrochemical technologies.
  • The guanine nucleobase, with its low oxidation potential, plays a central role in DNA charge transport mechanisms.

Purpose of the Study:

  • To investigate the fundamental mechanisms of charge migration, specifically hole hopping and trapping, in DNA.
  • To quantify hopping, trapping, and kinetic parameters using chemical yield data.

Main Methods:

  • Utilized chemical yield data to determine the relative reactivity of guanine cations.
  • Analyzed charge trapping by a triple guanine unit within DNA strands.
  • Estimated hole-hopping rates based on superexchange-mediated interactions.

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Main Results:

  • Quantified hopping, trapping, and chemical kinetic parameters for charge transport in DNA.
  • Estimated a hole-hopping rate of 10(9) s(-1) at 300 K for superexchange via two AT base pairs.
  • Inferred a maximal hole hopping distance of 300 +/- 70 Å in DNA duplexes with guanine separated by a single AT base pair.

Conclusions:

  • Hole transport in DNA is constrained by the number of mediating AT base pairs.
  • Electron transport is anticipated to be largely independent of DNA sequence due to similar reduction potentials of thymine and cytosine.