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Extensive electroporation abolishes experimentally induced shape transformations of erythrocytes: a consequence of
S Schwarz1, C W Haest, B Deuticke
1Institut für Physiologie, Medizinische Fakultät der RWTH, Universitätsklinikum, Pauwelsstr. 30, D-52057, Aachen, Germany.
Biochimica Et Biophysica Acta
|October 16, 1999
Abstract:
As shown in earlier work (M.M. Henszen et al., Mol. Membr. Biol. 14 (1997) 195-204), exposure of erythrocytes to single brief electric field pulses (5-7 kV cm(-1)) enhances the transbilayer mobility of phospholipids and produces echinocytes which can subsequently be transformed into stomatocytes in an ATP-dependent process. These shape transformations arise from partly reversible changes of the transbilayer disposition of phospholipids, in agreement with the bilayer couple concept. Extensive membrane modification by repetitive (