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Intermediate filament assembly: temperature sensitivity and polymorphism.

H Herrmann, U Aebi

    Cellular and Molecular Life Sciences : CMLS
    |October 16, 1999
    PubMed
    Summary
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    Intermediate filament (IF) proteins form polymers with distinct structures and properties. Their tissue-specific expression suggests specialized roles in maintaining cellular balance across different tissues.

    Area of Science:

    • Cellular Biology
    • Biochemistry
    • Molecular Biology

    Background:

    • Intermediate filament (IF) proteins constitute a large multigene family.
    • IF proteins polymerize into filaments with a consistent diameter of approximately 10 nm.
    • Cytoplasmic IF proteins share a common structural principle, forming extended coiled coils.

    Purpose of the Study:

    • To explore the variations in subunit arrangements and physical properties among different IF proteins.
    • To understand the functional significance of tissue-specific expression patterns of IF proteins.
    • To investigate the role of IF protein co-expression in forming heteropolymers and their impact on cellular homeostasis.

    Main Methods:

    • Analysis of gene expression patterns.
    • Biochemical characterization of IF protein polymers.

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  • Investigation of protein-protein interactions.

    • Main Results:

    • While sharing a basic structural unit, IF proteins exhibit diverse subunit arrangements and physical characteristics.
    • Tissue-specific expression is intricate, often involving co-expression of multiple IF proteins and associated proteins.
    • These variations suggest specialized evolutionary adaptations for distinct cellular functions.

    Conclusions:

    • The diversity in IF protein structure and expression points to specialized roles in tissue-specific cellular homeostasis.
    • Understanding these variations is crucial for comprehending the broader functions of the intermediate filament cytoskeleton.
    • IF proteins are key players in maintaining cellular integrity and function across various tissues.