Related Experiment Videos
Identifying appropriate subjects for abuse liability studies using prestudy pharmacological testing
U E Busto1, L A Zawertailo, H L Kaplan
1Facylty of Pharmacy, Behavioural Research Department, Centre for Addiction and Mental Health Addiction--Research Foundation Site, Toronto, Ontario, Canada. ubusto@arf.org
Summary
Prescreening nondrug abusers for subjective drug effects is crucial for reliable abuse liability testing. This method ensures accurate data collection on drug responses, improving study validity.
Area of Science:
- Pharmacology
- Clinical Research
- Drug Abuse Liability
Background:
- Traditional drug abuse liability studies use drug abusers.
- Nondrug abusers offer a diverse population for research.
- Assessing subjective responses in nondrug abusers is key.
Purpose of the Study:
- To evaluate subjective drug response patterns in nondrug abusers.
- To determine if nondrug abusers can reliably report drug effects.
- To validate a prescreening method for abuse liability studies.
Main Methods:
- Used hydromorphone and secobarbital for prescreening.
- Objective measures included pupil diameter and psychomotor impairment.
- Retested subjects with hydrocodone to confirm consistency.
Main Results:
- Some nondrug abusers could not reliably report drug effects.
- Inconsistent responders to hydromorphone also failed with hydrocodone.
- Consistent responders to hydromorphone reliably responded to another opiate.
Conclusions:
- Prescreening nondrug abusers is necessary for reliable subjective data.
- This method allows valid abuse liability assessment across various drug classes.
- Using nondrug abusers with prescreening offers advantages over using drug abusers.