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Published on: September 13, 2024
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with
T Suzuki1, N Segami, K Kaneyama
1Kanazawa Medical University, Department of Oral and Maxillofacial Surgery, Japan.
Objective:
Interleukin-1 beta appears to play an important role in the pathophysiology of joint diseases. The aim of this study was to analyze the expression of interleukin-1 beta in temporomandibular joint internal derangement.
Study Design:
Using an immunohistochemical technique with specific antibodies, we examined 20 human temporomandibular joint samples from patients with internal derangement of the temporomandibular joint: 5 extirpated disks and 15 biopsy specimens from the synovitic area of the temporomandibular joint upper compartment. We also examined 2 control specimens. The evaluation of interleukin-1 beta expression compared with clinical findings.
Results:
Interleukin-1 beta was predominantly localized in the synovial lining cells and endothelial cells of blood vessels. Statistically significant correlation was found between interleukin-1 beta expression and some clinical findings.
Conclusions:
The results suggest that interleukin-1 beta may be involved in the pathogenesis of temporomandibular joint internal derangement and that the intensity of interleukin-1 beta expression may correlate with clinical findings, especially pain.
