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[Adult's anaplastic CD30+ large cell lymphomas].

L Cany¹, P Soubeyran, V Boulanger

¹Service d'oncologie-radiothérapie, Clinique francheville, 38, boulevard de Vésone, 24000 Périgueux.

Bulletin Du Cancer

|October 16, 1999

Summary

Anaplastic large-cell lymphoma (ALCL) is a distinct non-Hodgkin lymphoma subtype. This review covers recent advances in understanding ALCL

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Area of Science:

Hematology
Oncology
Pathology

Background:

Anaplastic large-cell lymphoma (ALCL) was identified in 1985 and is a rare non-Hodgkin lymphoma.
ALCL is characterized by a specific chromosomal abnormality, t(2;5)(p23;q35), and has a bimodal age distribution.
Clinically, ALCL presents with nodal and extranodal involvement, particularly in the skin and lungs.

Purpose of the Study:

To review recent advancements in the knowledge, treatment, and prognosis of anaplastic large-cell lymphoma.
To highlight the classification and clinical characteristics of ALCL within the spectrum of lymphomas.
To discuss primitive cutaneous ALCL as part of CD30+ lymphoproliferative disorders.

Main Methods:

Literature review of recent advances in anaplastic large-cell lymphoma.

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Analysis of diagnostic criteria, including phenotype and chromosomal abnormalities.

Synthesis of clinical presentation, treatment strategies, and prognostic factors.

Main Results:

ALCL is a distinct entity within peripheral T-cell lymphomas and diffuse aggressive lymphomas.
The t(2;5) chromosomal abnormality is a key characteristic of ALCL.
Primitive cutaneous ALCL has a better prognosis compared to other aggressive lymphomas.

Conclusions:

Anaplastic large-cell lymphoma is a well-defined entity with specific genetic and clinical features.
Recent advances have improved the understanding of ALCL's biology and behavior.
Primitive cutaneous ALCL represents a favorable subgroup within CD30+ lymphoproliferative diseases.