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[Abdominal actinomycosis after stomach surgery in a patient with long-term rheumatoid arthritis treated with
1Abteilung für Allgemeine Innere Medizin, Medizinischen Klinik und Poliklinik.
History And Admission Findings:
A 78-year-old woman had a 30-year history of rheumatoid arthritis, of late treated with prednisolone and methotrexate. A week before admission she had first noticed a mass about 3 cm in diameter, at the lower end of a scar from a Billroth II gastric resection for gastric ulcer, performed 4 months before. She reported to have lost 6.5 kg in weight. On admission a moderately mobile, hard mass was palpated on the abdomen.
Investigations:
Ultrasound and computed tomography revealed a superficial, inhomogenous space-occupying lesion with poorly circumscribed margins.
Treatment And Course:
After two days the skin over the mass became reddened and a laparotomy was performed because an incarcerated herniation was suspected. An abscess and inflammatory adhesions were found in the area of the transverse colon, histologically shown to be a chronic purulent abscess with granular clusters of pathogens indicating actinomycosis. After 3 weeks' treatment with imipenem i.v. the patient became free of symptoms, oral doxycyclin was continued for a further 6 months.
Conclusion:
Actinomycosis should be considered in the differential diagnosis of a tumour of undetermined benignity in the region of the head, chest or abdomen in immunosuppressed patients. This bacterial infection should be thought of especially if the gastrointestinal mucosa has been penetrated by invasive procedures.
Insights
Actinomycosis, a bacterial infection, can mimic tumors in immunosuppressed patients, particularly after gastrointestinal procedures. Early diagnosis and antibiotic treatment are crucial for recovery.
Area of Science:
- Medical Microbiology
- Surgical Pathology
- Immunocompromised Host Research
Background:
- Rheumatoid arthritis patients on immunosuppressants (prednisolone, methotrexate) are at risk.
- Abdominal masses post-gastric surgery require thorough investigation.
Observation:
- A 78-year-old woman presented with a 3 cm abdominal mass near a Billroth II resection scar.
- Imaging revealed a superficial, inhomogeneous lesion with ill-defined borders.
- Reddening of the skin over the mass prompted surgical exploration.
Findings:
- Laparotomy identified an abscess and inflammatory adhesions, confirmed as actinomycosis.
- Microscopic examination revealed granular clusters of pathogens characteristic of actinomycosis.
- The patient had a history of rheumatoid arthritis and recent gastric surgery.
Implications:
- Actinomycosis should be considered in the differential diagnosis of abdominal masses in immunosuppressed individuals.
- Invasive gastrointestinal procedures may increase the risk of actinomycosis.
- Prompt antibiotic therapy (imipenem, doxycycline) led to symptom resolution.
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