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Design and interpretation of vaccine field studies
M E Halloran1, I M Longini, C J Struchiner
1Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Epidemiologic Reviews
|October 16, 1999
Abstract:
There are many different effects to consider when evaluating vaccines in the field. In this review, we have covered some of the various measures and issues related to study design and interpretation of the different measures. We emphasize that in designing and understanding vaccine studies, it is necessary to be specific about what the effect of interest is and about the assumptions underlying the interpretation of the results. Halloran et al. (81) present design, analysis, and interpretation of vaccine studies in more detail.