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Updated: May 6, 2026

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid

R Förster1, A Schubel, D Breitfeld

  • 1Molecular Tumorgenetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. rfoerst@mdc-berlin.de

Cell
|October 16, 1999
PubMed

Insights

The chemokine receptor CCR7 is crucial for immune surveillance, guiding immune cells to lymph nodes. CCR7-deficient mice exhibit impaired immune responses and altered lymphoid organ structure.

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • Immune surveillance relies on coordinated immune cell migration.
  • Understanding immune cell trafficking is key to primary immune responses.

Purpose of the Study:

  • To investigate the role of chemokine receptor CCR7 in immune cell organization and primary immune responses.
  • To analyze the impact of CCR7 deficiency on immune cell migration and lymphoid organ structure.

Main Methods:

  • Analysis of gene-targeted mice lacking functional CCR7.
  • Assessment of antibody response kinetics.
  • Evaluation of contact sensitivity and delayed type hypersensitivity reactions.
  • Morphological examination of secondary lymphoid organs.

Main Results:

  • CCR7-deficient mice displayed significantly delayed antibody responses.
  • Absence of contact sensitivity and delayed type hypersensitivity reactions in CCR7-deficient mice.
  • Profound morphological alterations in secondary lymphoid organs due to impaired lymphocyte migration.
  • Mature dendritic cells in CCR7-deficient mice failed to migrate to draining lymph nodes upon activation.

Conclusions:

  • Chemokine receptor CCR7 is essential for organizing primary immune responses.
  • CCR7 orchestrates the migration of immune cells, including dendritic cells, to secondary lymphoid organs.
  • Proper function of CCR7 is required for the rapid initiation of adaptive immunity and the formation of lymphoid organ microarchitecture.

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