Ontogeny of nitric oxide synthase I and III protein expression and enzymatic activity in the guinea pig hippocampus

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K A Kimura1, J N Reynolds, J F Brien

  • 1Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.

Brain Research. Developmental Brain Research
|October 16, 1999
PubMed

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...