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Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity
1Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China.
Bioorganic & Medicinal Chemistry Letters
|October 16, 1999
Abstract:
A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free omega-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit.