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Antagonism of the TXA2 receptor by seratrodast: a structural approach
J Wouters1, F Durant, B Masereel
1Dept. of Chemistry, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium. jwouters@scf.fundp.ac.be
Bioorganic & Medicinal Chemistry Letters
|October 16, 1999
Abstract:
The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.