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Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors

F M Martin1, R P Beckett, C L Bellamy

  • 1British Biotech Pharmaceuticals Limited, Cowley, Oxford. martinf@britbio.co.uk

Bioorganic & Medicinal Chemistry Letters
|October 16, 1999
PubMed

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
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