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Related Experiment Videos

New technique for vagal nerve stimulation.

J J Goldberger1, A H Kadish, D Johnson

  • 1Department of Medicine and the Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA. j-goldberger@nwu.edu

Journal of Neuroscience Methods
|October 16, 1999
PubMed
Summary

Transvascular stimulation of the vagus nerve via the carotid artery in dogs effectively increased parasympathetic tone. This method successfully modulated cardiac electrophysiology and blood pressure, demonstrating a novel approach to vagal nerve stimulation.

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Area of Science:

  • Cardiovascular Physiology
  • Neurostimulation
  • Medical Device Technology

Background:

  • The vagus nerve runs alongside the carotid artery and internal jugular vein in a neurovascular bundle.
  • Previous methods for vagal nerve stimulation are not detailed, but this study explores a novel transvascular approach.

Purpose of the Study:

  • To determine if transvascular stimulation through the carotid artery can directly stimulate the vagus nerve in dogs.
  • To assess the impact of such stimulation on parasympathetic tone and cardiac electrophysiology.

Main Methods:

  • A steerable electrode catheter was inserted into the right carotid artery of five anesthetized dogs under fluoroscopic guidance.
  • Multipolar catheters were placed in the right atrium and ventricle via the femoral vein to record cardiac electrical activity.

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Main Results:

  • Vagal nerve stimulation was achieved in all dogs using 10-30 mA outputs.
  • Stimulation significantly increased sinus cycle length, AH interval, and AV nodal effective refractory period, while shortening the atrial effective refractory period.
  • Systolic blood pressure decreased, and atrial fibrillation was induced in 3 of 5 animals during stimulation.

Conclusions:

  • Cardiac parasympathetic stimulation is feasible by catheter placement within the carotid artery's neurovascular bundle.
  • This technique influences cardiac electrophysiology and can be used to modulate autonomic tone.