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HLA-DQ1 associated with reflex sympathetic dystrophy
M A Kemler1, A C van de Vusse, E M van den Berg-Loonen
1Department of Surgery, Maastricht University Hospital, The Netherlands.
Neurology
|October 16, 1999
Abstract:
Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The frequency of HLA-DQ1 was found to be significantly increased compared with control frequencies. The association provides an indication for an organic basis of RSD.