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Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis
M Fernandez-Arquero1, R Arroyo, A Rubio
1Department of Immunology, San Carlos University Hospital, Madrid, Spain.
Neurology
|October 16, 1999
Abstract:
The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.