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Skin anatomy, physiology, and pathophysiology.

A B Wysocki1

  • 1Wound Healing Laboratory, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland 20892-0967, USA. annette_wysocki@nih.gov

The Nursing Clinics of North America
|October 16, 1999
PubMed
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This article reviews human skin structure and function, covering its protective and immune roles. It details key concepts for understanding wound healing and skin pathophysiology for clinicians.

Area of Science:

  • Dermatology
  • Human Physiology
  • Wound Healing Research

Background:

  • Human skin is the largest organ, performing vital protective, sensory, and thermoregulatory functions.
  • Understanding skin structure (epidermis, dermis, basement membrane zone) is crucial for clinical practice.
  • Knowledge of skin's biochemical, metabolic, and immune functions is essential.

Purpose of the Study:

  • To provide clinicians and researchers with essential knowledge of human skin structure and function.
  • To highlight key and emerging concepts relevant to understanding skin pathophysiology.
  • To address critical topics in wound healing and skin injury evaluation.

Main Methods:

  • Review of established scientific literature on skin biology.
  • Synthesis of information on skin layers, functions, and immune responses.

Related Experiment Videos

  • Discussion of pathophysiological mechanisms and clinical relevance.

    • Main Results:

    • Detailed explanation of skin's dual-layer structure and its functions.
    • Elucidation of critical concepts including acute vs. chronic wounds and injury assessment.
    • Exploration of ischemic-reperfusion injury, skin immunity, and matrix dynamics.

    Conclusions:

    • Comprehensive understanding of skin structure and function is fundamental for medical professionals.
    • Key concepts discussed are vital for diagnosing and managing skin conditions and injuries.
    • This review equips clinicians with knowledge on advanced topics like biomolecules and matrix turnover.