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The use of insulin alone and in combination with oral agents in type 2 diabetes
1Department of Medicine, and Director, Diabetes Care Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7172, USA. jbuse@med.unc.edu
Abstract:
To achieve optimal outcomes in patients with type 2 diabetes, clinical trial data suggest that near normal glycemic control should be targeted. Insulin is arguably the most effective treatment available for diabetes and yet many patients remain poorly controlled without the benefit of insulin therapy. Discussion of its putative risks and benefits as well as the barriers to its wider use both in the context of monotherapy and in combination with oral antidiabetic agents is provided. Application of the strategies and principles of insulin therapy in type 2 diabetes should minimize the burden of complications in patients with the disease.