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Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence
D E Comings1, N Gonzalez, S Wu
1Department of Medical Genetics, City of Hope Medical Center, Duarte, CA, USA.
Molecular Psychiatry
|October 19, 1999
Abstract:
We examined the hypothesis that the dopamine D3 receptor gene (DRD3) is a susceptibility factor for cocaine dependence. The MscI/BalI polymorphism of the DRD3 gene was examined in 47 Caucasian subjects with cocaine dependence and 305 Caucasian controls. Based on prior studies with a range of psychiatric disorders we hypothesized there would be a decrease in the frequency of the 12 genotype in the patient sample (increased homozygosity). We observed a significant decrease in the frequency of 12 heterozygotes in subjects with cocaine dependence (29.8%) vs controls (46.9%) (P