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[Infections and cardiovascular disease].

H J Kolmos1, C N Gluud

  • 1Klinisk mikrobiologisk afdeling, H:S Hvidovre Hospital. hans.joern.kolmos@hh.hosp.dk

Ugeskrift for Laeger
|October 19, 1999
PubMed
Summary

Infections like Chlamydia pneumoniae (Cp) and cytomegalovirus (CMV) are linked to cardiovascular disease risk. Further research is needed on microbial roles and antibiotic treatments for atherosclerotic conditions.

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Area of Science:

  • Microbiology and Immunology
  • Cardiovascular Medicine
  • Infectious Diseases

Context:

  • Epidemiological data links respiratory and dental infections to increased atherosclerotic cardiovascular disease (ASCVD) risk.
  • Specific microorganisms, notably Chlamydia pneumoniae (Cp) and cytomegalovirus (CMV), are implicated in ASCVD pathogenesis.
  • Inflammatory markers are consistently associated with atherosclerotic cardiovascular disease.

Purpose:

  • To review the evidence linking microbial infections to atherosclerotic cardiovascular disease.
  • To explore the potential role of Chlamydia pneumoniae and cytomegalovirus in cardiovascular pathology.
  • To highlight the need for further investigation into the clinical efficacy of antibiotic therapies for cardiovascular disease.

Summary:

  • Chlamydia pneumoniae (Cp) is frequently found in atherosclerotic plaques, and macrolide antibiotic treatment may benefit ischemic heart disease.
  • Cytomegalovirus (CMV) appears to contribute to coronary stenosis after bypass surgery and heart transplantation.
  • The pathogenetic role of microorganisms in cardiovascular disease is likely mediated through infection-induced inflammatory responses.

Impact:

  • Underscores the urgent need for more robust evidence on the contribution of microorganisms to cardiovascular disease.
  • Suggests a potential therapeutic avenue through antibiotic treatment for specific cardiovascular conditions.
  • Emphasizes the importance of understanding the interplay between infection, inflammation, and atherosclerosis.

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