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Evolutionary changes reflected by the cellular amino acid composition.

K Sorimachi1

  • 1Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.

Amino Acids
|October 19, 1999
PubMed
Summary
This summary is machine-generated.

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Cellular amino acid composition reveals evolutionary divergence among diverse organisms. Despite evolutionary changes, a fundamental amino acid pattern persists, suggesting a common origin for primitive life forms.

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Microbiology

Background:

  • Cellular protein amino acid composition is a potential marker for biological evolution.
  • Investigating amino acid ratios can quantify evolutionary divergence between species.

Purpose of the Study:

  • To compare amino acid composition across diverse organisms to understand biological evolution.
  • To determine if amino acid ratios correlate with evolutionary divergence.

Main Methods:

  • Analysis of 17 amino acids in cell-proteins from bacteria, algae, fungi, slime mold, protozoa, and vertebrates.
  • Comparison of amino acid ratios between different biological groups.

Main Results:

  • Gram-negative bacteria (Escherichia coli, Klebsiella, Proteus, Vibrio alginolyticus) showed identical amino acid composition.

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  • Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) differed from each other and Gram-negative bacteria.
  • Blue-green alga (Cyanobacterium, Chroococidiopsis) composition was similar to E. coli, while green alga (Chlorella) and other eukaryotes showed marked differences.

    • Conclusions:

    • Changes in cellular amino acid composition reflect evolutionary divergence.
    • A basic amino acid composition pattern is conserved across diverse organisms despite long evolutionary periods.
    • Primitive life forms likely shared a similar amino acid composition at the end of prebiotic evolution.