Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left atrial appendage: structure, function, and role in thromboembolism.

N M Al-Saady1, O A Obel, A J Camm

  • 1Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. nalsaady@sghms.ac.uk

Heart (British Cardiac Society)
|October 20, 1999
PubMed
Summary

The left atrial appendage (LAA) functions as a decompression chamber due to its unique properties. However, interventions like LAA obliteration may reduce thromboembolism risk but can impact atrial compliance and ANF secretion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atrial premature beats preceding episodes of paroxysmal atrial fibrillation: factorial analysis of a prediction system.

Pacing and clinical electrophysiology : PACE·1997
Same author

Exercise-induced T-wave alternans as a marker of high risk in patients with hypertrophic cardiomyopathy.

Japanese circulation journal·1997
Same author

Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction.

Circulation·1997
Same author

Chlamydia pneumoniae and coronary heart disease.

BMJ (Clinical research ed.)·1997
Same author

Amiodarone after myocardial infarction: EMIAT and CAMIAT trials.

Lancet (London, England)·1997
Same author

Use of troponin-T concentration and kinase isoforms for quantitation of myocardial injury induced by radiofrequency catheter ablation.

European heart journal·1997

Area of Science:

  • Cardiology
  • Embryology
  • Physiology

Background:

  • The left atrial appendage (LAA) originates from the primary atrium during embryonic development.
  • It possesses distinct developmental, ultrastructural, and physiological features compared to the main left atrium.
  • Its anatomical proximity to the left ventricle influences its function.

Purpose of the Study:

  • To elucidate the distinct physiological roles and anatomical relations of the LAA.
  • To understand the factors contributing to thrombus formation in the LAA.
  • To evaluate the consequences of LAA interventions on cardiac function.

Main Methods:

  • Review of developmental and anatomical data.
  • Analysis of physiological properties including distensibility and neuroanatomy.

Related Experiment Videos

  • Examination of factors contributing to thrombus formation.
  • Assessment of potential sequelae from LAA obliteration or amputation.

    • Main Results:

    • The LAA acts as a decompression chamber due to its position, distensibility, atrial natriuretic factor (ANF) content, and neuronal structure.
    • Thrombus formation in the LAA is common in conditions like atrial fibrillation and mitral valve disease, likely due to blood stasis.
    • LAA obliteration may reduce thromboembolic risk but can lead to reduced atrial compliance and ANF secretion.

    Conclusions:

    • The LAA has specialized physiological functions, including acting as a decompression chamber and secreting ANF.
    • Blood stasis within the LAA's unique shape and trabeculations contributes to thrombus formation.
    • Interventions targeting the LAA require careful consideration of potential adverse physiological effects.