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The effect of CO2 pneumoperitoneum on the growth of a solid colon carcinoma in rats
M Pauwels1, P Lauwers, J Hendriks
1Laboratory of Experimental Surgery, University of Antwerp, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium.
Background:
In order to investigate the effect of carbon dioxide (CO(2)) pneumoperitoneum on solid colon carcinomas, we used a colon anastomosis tumor model in 30 male syngeneic WAG rats, which were divided, at random into three groups.
Methods:
In all rats, 10(6) CC531 S colon carcinoma cells were injected as an enema into the colon. Subsequently, a transection and a reanastomosis of the colon descendens was performed via laparotomy. After 2 weeks, group 1 (n = 10) was anesthetized as an anesthesia control group. Group 2 (n = 10) had a laparotomy that was closed after 20 min. In group 3 (n = 10), a CO(2) pneumoperitoneum of
Results:
At necroscopy tumor growth was found in 16 rats (group 1: six; group 2: five; group 3: five). No difference in tumor growth (weight or volume) was found between the three groups.
Conclusion:
In our solid colon carcinoma model, CO(2) pneumoperitoneum did not enhance tumor growth.