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Terfenadine prevents NMDA receptor-dependent and -independent toxicity following sodium channel activation
R Díaz-Trelles1, A Novelli, G Puia
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, E-33071, Oviedo, Spain.
Brain Research
|October 20, 1999
Abstract:
Exposure of cultured cerebellar neurons to terfenadine prevented the N-methyl-D-aspartate (NMDA) receptor-mediated early appearance (30 min) of toxicity signs induced by the voltage sensitive sodium channel (VSSC) activator veratridine. Delayed neurotoxicity by veratridine (24 h) occurring independently from NMDA receptor activation was also prevented by terfenadine. Terfenadine did not protect from excitotoxicity following direct exposure of neurons to glutamate. Our results suggest that terfenadine may modulate endogenous glutamate release following activation of VSSCs.