Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory loss in multiple sclerosis.

R Zivadinov1, M Zorzon, L Monti Bragadin

  • 1Neurological Clinic, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.

Journal of the Neurological Sciences
|October 20, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity does not increase the risk of side effects and complications of egg retrieval: delaying oocyte retrieval in obese patients is not a good strategy.

European review for medical and pharmacological sciences·2023
Same author

Evaluation of the ideal vaginal Progesterone effectiveness doses for luteal support in embryo thawing cycles after endometrial preparation without using the GnRh analogue.

European review for medical and pharmacological sciences·2023
Same author

Heme Oxygenase-1/High Mobility Group Box 1 Pathway May Have a Possible Role in COVID-19 ARDS (Acute Respiratory Distress Syndrome): A Pilot Histological Study.

Advances in experimental medicine and biology·2022
Same author

Blue mass in pelvis: serous cystadenofibroma of peritoneum.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021
Same author

Use of ceramic bearings in hip arthroplasty: correct implantation and review of clinical and radiographic results.

Journal of biological regulators and homeostatic agents·2020
Same author

Intramedullary antibiotic coated nail in tibial fracture: a systematic review.

Journal of biological regulators and homeostatic agents·2020
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Multiple sclerosis (MS) patients show impaired odor identification compared to healthy individuals. This decreased smell ability correlates with neurological impairment, anxiety, and depression symptoms in MS patients.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Psychiatry

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Olfactory dysfunction is an underrecognized symptom in MS.
  • Assessing smell identification can provide insights into MS progression.

Purpose of the Study:

  • To evaluate odor identification ability in multiple sclerosis (MS) patients.
  • To investigate correlations between smell identification scores and clinical variables in MS.

Main Methods:

  • A case-control study comparing 40 MS patients with 40 healthy controls.
  • Utilized the Cross-Cultural Smell Identification Test (CC-SIT).
  • Assessed neurological impairment, disability, cognitive, and psychological functioning.

Related Experiment Videos

Main Results:

  • MS patients demonstrated significantly poorer odor identification than controls (P<0.001).
  • Olfactory dysfunction was present in 22.5% of MS patients.
  • Smell identification scores correlated negatively with anxiety (r=-0.43), depression (r=-0.42), and neurological impairment severity (r=-0.32).

Conclusions:

  • A significant number of MS patients experience impaired olfactory function, often without self-reporting.
  • Decreased odor identification is associated with increased anxiety, depression, and neurological severity in MS.
  • Olfactory assessment should be considered in the comprehensive evaluation of MS patients.