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Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromsø study
R Jorde1, K H Bonaa, J Sundsfjord
1Department of Medicine, University Hospital of Tromso, Tromso, Norway. medrj@rito.no
Insights
Serum parathyroid hormone (PTH) is linked to higher blood pressure in women. This cross-sectional study found a strong positive association between PTH levels and blood pressure in females, suggesting a potential link for hypertension management.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Human Physiology
Background:
- Serum parathyroid hormone (PTH) plays a crucial role in calcium homeostasis.
- Elevated PTH levels have been anecdotally linked to cardiovascular issues.
- Understanding the relationship between PTH and blood pressure is vital for public health.
Purpose of the Study:
- To investigate the association between serum ionised calcium, serum parathyroid hormone (PTH), and blood pressure.
- To determine if PTH levels correlate with hypertension in a general population.
- To explore potential sex-based differences in these associations.
Main Methods:
- Cross-sectional population-based study design.
- Measurement of blood pressure, BMI, serum ionised calcium, and serum PTH in 946 participants (460 males, 486 females).
- Multiple linear regression analysis to assess associations, controlling for potential confounders.
Main Results:
- A significant negative association was observed between serum ionised calcium and PTH in subjects with lower calcium levels (P<0.01).
- No significant association was found between blood pressure and serum ionised calcium.
- Serum PTH showed a significant positive association with both systolic and diastolic blood pressure in women (P<0.01), but not in men. Females with hypertension exhibited higher serum PTH levels than normotensive females (P<0.01).
Conclusions:
- Serum parathyroid hormone (PTH) is strongly and positively associated with blood pressure in women.
- These findings suggest a potential role for PTH in the development or exacerbation of hypertension in females.
- Further research is warranted to elucidate the causal mechanisms and clinical implications.
Objective:
To study associations between serum ionised calcium, serum parathyroid hormone (PTH) and blood pressure.
Design:
A population based, cross-sectional study was used.
Methods:
Blood pressure, body mass index, serum ionised calcium and serum PTH were measured in 460 males and 486 females in the Tromso study in 1994/1995. None were on medication for hypertension. The data were analysed with a multiple linear regression model.
Results:
When looking at subjects with serum ionised calcium<1.39mmol/l, there was a significant negative association (P<0.01) between serum ionised calcium and PTH. There was no association between blood pressure and serum ionised calcium. In both sexes there was a significant positive association between age and serum PTH (P<0.01). For women, but not for men, there was a significant positive association between serum PTH and systolic and diastolic blood pressure (P<0.01). Within each age group there was a difference in both systolic and diastolic blood pressure of 3-10mmHg between the upper and lower serum PTH halves of the female population. Females with hypertension had significantly higher serum PTH levels than the normotensive females (P<0.01).
Conclusion:
Serum PTH is strongly and positively associated with blood pressure in women.