Towards an integration of biochemical and biophysical models of neuronal information processing: a case study in the...

The experimental and theoretical study of intracellular biochemical signaling mechanisms lags considerably behind our understanding of electrical processes of neuronal membranes. Both signaling processes, however, are extensively intertwined and can be analyzed and modeled using formally similar mathematical tools. With the nigro-striatal system as an example, we review various formal approaches to describe metabotropic signaling in dopamine- and calcium-dependent pathways and their interactions with electrical membrane processes. These demonstrate the feasibility of synthetic modeling and afford insights into a variety of specific signaling mechanisms. Extending and linking hitherto isolated models has the potential to transcend descriptive levels and to provide a fuller understanding of the molecular basis of macroscopic information processing in the central nervous system.