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Terminal differentiation and left-handed Z-DNA: a review
C E Gagna1, H r Kuo, W C Lambert
1Department of Pathology and Laboratory Medicine, Rm #C508c, University of Medicine and Dentistry of New Jersey-Medical School, 185 S. Orange Avenue, Newark, NJ 07103, USA.
Cell Biology International
|October 21, 1999
Abstract:
Nucleic acids control the expression of genes, and different conformations of DNA structure may regulate cell death. Left-handed Z-DNA, which is speculated to function as a transcriptional enhancer, may be directly influenced by the destructive effects of terminal differentiation. The nicking-denaturation of double-stranded Z-DNA could possibly initiate and enhance terminal differentiation within specific tissues.