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Cellular toxicity of N-substituted 2,2'-dicarboxamidodiphenyldisulphides with high antimicrobial activity
E Favari1, E Bernardini, F Bernini
1Institute of Pharmacology and Pharmacognosy, University of Parma, Parma, Italy.
Pharmacological Research
|October 21, 1999
Abstract:
In the present paper we evaluate the cellular toxicity of some N-substituted 2,2'-dicarboxamidodiphenyldisulphides with high antimicrobial activities, in view of their potential application in humans or animals. The toxicological studies have been conducted in the murine cell line of 3T3 fibroblasts as eucaryotic cellular model. Our results have allowed the identification of a series of derivatives exhibiting antimicrobial activity and low cellular toxicity. Structure-cytotoxic activity relationships are also discussed.