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Related Experiment Videos

The best donor.

A Shulman1, Y Frenkel, J Dor

  • 1The IVF Unit, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

Human Reproduction (Oxford, England)
|October 21, 1999
PubMed
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Shared egg donation programs show success rates influenced by donor infertility causes and recipient age. Donor age over 35 and recipient age over 50 negatively impact pregnancy outcomes in fertility treatments.

Area of Science:

  • Reproductive Medicine
  • Infertility Treatment
  • Assisted Reproductive Technology

Background:

  • Oocyte donation is a widely used fertility treatment for various infertility conditions.
  • Shared egg donation programs offer a cost-effective option but require careful donor-recipient matching.

Purpose of the Study:

  • To evaluate the success rates of a shared egg donation program.
  • To identify characteristics of successful donor-recipient pairs within program limitations.

Main Methods:

  • Analysis of consecutive egg donation cycles from January 1995 to December 1996.
  • Matching 383 donor cycles with 946 recipient cycles.
  • Statistical analysis of pregnancy rates based on donor and recipient factors.

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Main Results:

  • Clinical pregnancy rates were 23.5% for donors and 16.7% for recipients.
  • Endometriosis in donors or recipients significantly reduced pregnancy rates.
  • Donor age >35 years and recipient age >50 years were associated with lower pregnancy rates.
  • Recipient age >45 years correlated with increased abortion rates.
  • Intracytoplasmic sperm injection (ICSI) for severe male factor infertility yielded comparable pregnancy rates to standard in-vitro fertilization (IVF).

Conclusions:

  • Recipient pregnancy outcomes in shared egg donation are primarily determined by donor infertility etiologies and recipient age.
  • Donor age does not affect recipient pregnancy rates, but donors over 35 show decreased success.
  • Recipient age is a critical factor, with advanced maternal age (>45-50) linked to reduced pregnancy and increased abortion rates.