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[Cognitive and behavioral disorders in Parkinson disease]
1Unidad de Neurología del Comportamiento, Universidad de Harvard, Boston, MA, USA. apleone@caregroup.harvard.edu
Revista De Neurologia
|October 21, 1999
Summary
Cognitive and behavioral disorders are common in Parkinson's disease (PD). Current treatments remain symptomatic and controversial due to a lack of pathophysiological understanding.
Area of Science:
- Neuroscience
- Neurology
Context:
- Parkinson's disease (PD) frequently presents with cognitive and behavioral disorders.
- These symptoms significantly impact patient quality of life and disease management.
Purpose:
- To explore practical treatment strategies for Parkinson's disease patients experiencing cognitive and behavioral issues.
- To review the underlying pathophysiology contributing to these disorders.
Summary:
- Understanding basal ganglia physiology and its connections offers insights into PD-related cognitive and behavioral disorders.
- Lesions in subcorticocortical systems and cortical pathology (Lewy bodies, neuritic plaques) may explain a spectrum of symptoms from depression to dementia.
- Current treatment approaches are symptomatic, complex, and controversial due to incomplete pathophysiological models.
Impact:
- Highlights the need for further research based on pathophysiological models to improve treatment efficacy.
- Emphasizes the current limitations in effectively managing cognitive and behavioral symptoms in Parkinson's disease.