[Cardiopathies associated with a low embolic risk]
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1Service de Neurologie, Centre R. Garcin, Hôpital Sainte-Anne 1, Paris.
Insights
Identifying the cause of stroke is crucial. While cardiac imaging reveals potential sources like patent foramen ovale, their direct link to stroke requires further research to guide effective treatment.
Area of Science:
- Cardiology and Neurology
- Cardiovascular Imaging
- Cerebrovascular Disease
Context:
- Advancements in cardiac imaging identify potential cardioembolic sources (e.g., patent foramen ovale, atrial septal aneurysm, cardiac strands, mitral valve prolapse).
- A significant prevalence of these cardiac findings exists in individuals without a history of stroke.
- The etiological role of these cardiac abnormalities in stroke causation remains unclear.
Purpose:
- To investigate the association between cardiac abnormalities and stroke.
- To determine if identified cardiac findings are causative or incidental in stroke patients.
- To define risk stratification and therapeutic intervention benefits for stroke associated with cardiac abnormalities.
Summary:
- Cardiac imaging frequently detects abnormalities like patent foramen ovale, but their causal link to stroke is often ambiguous, especially given their prevalence in stroke-free individuals.
- These cardiopathies are generally associated with a low stroke risk.
- Further studies are essential to elucidate stroke risk, underlying mechanisms, identify high-risk patients, and evaluate treatment efficacy.
Impact:
- Clarifying the role of cardiac abnormalities in stroke will enable precise patient selection for interventions.
- Avoiding unnecessary treatments reduces patient exposure to potential therapeutic complications.
- Improved understanding facilitates evidence-based guidelines for managing cardioembolic stroke.
Abstract:
Advances in cardiac imaging techniques have resulted in the recognition of several potential cardioembolic sources (such as patent foramen ovale, atrial septal aneurysm, strands, mitral valve prolapse), but it is often not clear whether the findings, which often have a substantial prevalence in patients without stroke, are merely an associated abnormality or a direct cause of the stroke. Overall, these cardiopathies are associated with a low risk of stroke. Studies are needed to better define the risk and mechanisms of stroke associated with these cardiac abnormalities, to determine which patients are at increased risk of stroke and to assess the potential benefits from therapeutic interventions. Unless we can define strict indications for therapeutic interventions, we risk ending up with exposing some patients to unnecessary complications of treatment.
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