Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signaling pathways and diabetic embryopathy.

N Dhanasekaran1, Y K Wu, E A Reece

  • 1Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

Seminars in Reproductive Endocrinology
|October 21, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[ELOC-mutated renal cell carcinoma: from tumor genesis to clinical implications].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2025
Same author

[Ultrasonic-assisted alkaline dilution-inductively coupled plasma mass spectrometry for the determination of total bromine in whole blood].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

Proton Compton Scattering from Linearly Polarized Gamma Rays.

Physical review letters·2022
Same author

[Centronuclear myopathy: clinical characteristics and MRI image features of oral and maxillofacial region].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2018
Same author

Aberrant activation of the type I interferon system may contribute to the pathogenesis of anti-melanoma differentiation-associated gene 5 dermatomyositis.

The British journal of dermatology·2018
Same author

[Features of facioscapulohumeral muscular dystrophy in oral and maxillofacial region and MRI analysis of facial muscles].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2016

Diabetic embryopathy, a major cause of birth defects in infants of diabetic mothers, stems from defective maternal-embryonic signaling. Research points to the eicosanoid signaling pathway as a critical factor, offering therapeutic targets.

Area of Science:

  • Developmental Biology
  • Reproductive Medicine
  • Endocrinology

Background:

  • Diabetic embryopathy is a primary cause of neonatal mortality and congenital abnormalities in infants born to diabetic mothers.
  • Embryonic development relies heavily on maternal and embryonic signaling pathways.
  • Defects in these signaling mechanisms are implicated in the development of diabetic embryopathy.

Purpose of the Study:

  • To investigate the underlying mechanisms of diabetic embryopathy.
  • To identify critical signaling pathways involved in diabetic embryopathy.
  • To explore potential therapeutic targets for intervention.

Main Methods:

  • Analysis of recent studies from multiple laboratories.
  • Examination of signal-transducer convergence.

Related Experiment Videos

  • Focus on the eicosanoid signaling pathway.

    • Main Results:

    • Diabetic embryopathy has a multifactorial basis.
    • Various signal-transducers converge to regulate the eicosanoid signaling pathway.
    • This pathway appears critical in the etiology of diabetic embryopathy.

    Conclusions:

    • The eicosanoid signaling pathway is central to diabetic embryopathy.
    • Characterizing regulatory components of this pathway can reveal therapeutic intervention points.
    • Understanding these signaling loci may lead to new treatments for affected infants.