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Fusidic acid in vitro activity.

P Collignon¹, J Turnidge

¹Department of Microbiology, ACT Pathology, The Canberra Hospital, Australia. collignon@dpa.act.gov.au

International Journal of Antimicrobial Agents

|October 21, 1999

Summary

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Fusidic acid effectively inhibits bacterial protein synthesis, particularly against staphylococci. However, its in vitro testing requires careful consideration due to protein binding and inoculum effects.

Area of Science:

Microbiology
Pharmacology

Background:

Fusidic acid is a narrow-spectrum antibiotic targeting bacterial protein synthesis.
Its efficacy is primarily against staphylococci, including methicillin-resistant strains.

Purpose of the Study:

To detail the antimicrobial spectrum and characteristics of fusidic acid.
To highlight factors influencing in vitro susceptibility testing and clinical interpretation.

Main Methods:

Review of existing literature on fusidic acid's mechanism of action, spectrum, and resistance.
Analysis of factors affecting in vitro testing, such as protein binding and inoculum effect.

Main Results:

Fusidic acid inhibits elongation factor G, crucial for bacterial protein synthesis.

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High protein binding affects in vitro susceptibility testing; a breakpoint of 1-2 mg/L is common.

It demonstrates potent activity against Staphylococcus species, moderate activity against some Gram-positives and Neisseria spp., but lacks activity against aerobic Gram-negatives.

Conclusions:

Fusidic acid is a bacteriostatic agent, primarily effective against staphylococci.
Understanding its pharmacokinetic and pharmacodynamic properties is essential for optimizing treatment and interpreting susceptibility data.