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Risperidone-induced absence of ejaculation.

¹Servizio Psichiatrico di Diagnosi e Cura, Ospedale Santo Spirito, Dipartimento di Salute Mentale, USL RM E, Rome, Italy. raja.russo@iol.it

International Clinical Psychopharmacology

|October 21, 1999

Summary

Risperidone can cause ejaculation absence, a rare side effect in men. This dysfunction may stem from the drug's alpha1-adrenergic antagonist properties, impacting sexual health.

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Area of Science:

Pharmacology
Neuroscience
Urology

Background:

Risperidone is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
Sexual dysfunction is a known potential side effect of antipsychotic medications.
Ejaculation disorders are less commonly reported with risperidone compared to other antipsychotics.

Observation:

Two male patients receiving risperidone treatment experienced a complete absence of ejaculation (anejaculation).
This adverse event occurred despite adequate sexual arousal and intercourse.
No other significant changes in sexual function were reported by the patients.

Findings:

The primary finding is the rare occurrence of anejaculation in patients treated with risperidone.
The mechanism is hypothesized to involve the alpha1-adrenergic antagonist activity of risperidone.
This action could interfere with the sympathetic nervous system's role in ejaculation.

Implications:

Clinicians should be aware of the potential for risperidone-induced ejaculation dysfunction.
Further research is needed to elucidate the precise neurobiological mechanisms involved.
Management strategies may include dose adjustment or switching to alternative antipsychotics if this side effect is bothersome.

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