Treating asthma with anti-IgE or anti-IL5
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Updated: Aug 17, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
1The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Göteborg University, Guldhedsgatan, 10A, 413 46 Gothenburg, Sweden. jan.lotvall@mednet.gu.se
Abstract:
In the last decades, several key mechanisms driving asthma pathophysiooogy have been discovered. These include the role of IgE in allergic disease, and the role of IL-5 in eosinophilic inflammation. In the last few years, tools to block each of these have been developed. At this time, early clinical studies with neutralizing antibodies against both IgE and IL-5 have been performed in asthma patients, with promising results, and larger studies are underway. The mechanisms of, and possible role of, both anti-IgE and anti-IL-5 treatment in asthma are discussed in this review article.
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