Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein E polymorphism in IgA nephropathy.

N Yorioka1, Y Nishida, H Oda

  • 12nd Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan.

Nephron
|October 26, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proximal extension of cap polyposis confirmed by colonoscopy.

Gastrointestinal endoscopy·2001
Same author

GC/MS analysis of polybrominated diphenyl ethers in fish collected from the Inland Sea of Seto, Japan.

Chemosphere·2001
Same author

Involuted intraosseous lipoma of the sacrum showing high signal intensity on T1-weighted magnetic resonance imaging (MRI).

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·2001
Same author

Involvement of prostaglandin E(2) in interleukin-1alpha-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis.

The Journal of clinical endocrinology and metabolism·2001
Same author

[Weight reduction improves high blood pressure and microalbuminuria in hypertensive patients with obesity].

Nihon Jinzo Gakkai shi·2001
Same author

Mechanism of increased serum soluble interleukin-2 receptor levels in patients on continuous ambulatory peritoneal dialysis.

Scandinavian journal of urology and nephrology·2001

The apolipoprotein E2 (Apo E2) phenotype is linked to more severe kidney damage in IgA nephropathy patients. This finding may help predict disease progression and guide treatment strategies for this kidney condition.

Area of Science:

  • Nephrology
  • Genetics
  • Biochemistry

Background:

  • Immunoglobulin A (IgA) nephropathy is a common kidney disease.
  • The role of apolipoprotein E (Apo E) phenotypes in IgA nephropathy progression is not fully understood.
  • Apolipoprotein E is involved in lipid metabolism and may influence inflammatory processes in kidney disease.

Purpose of the Study:

  • To investigate the association between apolipoprotein E (Apo E) phenotypes and the severity of histological damage in patients with IgA nephropathy.
  • To explore the relationship between Apo E phenotypes, clinical factors, and kidney damage.
  • To determine if specific Apo E alleles or phenotypes are risk factors for more severe IgA nephropathy.

Main Methods:

  • A cohort of 104 patients diagnosed with IgA nephropathy was studied.

Related Experiment Videos

  • Apolipoprotein E (Apo E) phenotypes were determined using plasma isoelectric focusing and immunoblotting.
  • Frequencies of Apo E alleles and phenotypes were calculated and compared between patients with different levels of histological damage.

    • Main Results:

    • No significant differences in Apo E phenotype or allele frequencies were observed between IgA nephropathy patients and healthy controls.
    • The Apo E2 phenotype was found to be significantly more prevalent in patients with severe histological damage compared to those with mild damage.
    • Elevated serum triglyceride levels were also noted in patients with severe histological damage and the Apo E2 phenotype.

    Conclusions:

    • The apolipoprotein E2 (Apo E2) phenotype is associated with increased histological damage severity in IgA nephropathy.
    • This association suggests Apo E2 may be a biomarker for predicting disease severity in IgA nephropathy.
    • Further research is warranted to elucidate the mechanisms linking Apo E2 to IgA nephropathy progression.