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Related Experiment Videos

Improved dissolution behavior of fenbufen by spherical crystallization.

P Di Martino1, C Barthélémy, F Piva

  • 1University of Camerino, Dip. Scienze Chimiche, Camerino, Italy.

Drug Development and Industrial Pharmacy
|October 26, 1999
PubMed
Summary
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Spherical crystallization significantly improved fenbufen

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Fenbufen exhibits poor water solubility and wettability, impacting gastrointestinal absorption and bioavailability.
  • Low solubility, especially at acidic pH, poses challenges for effective drug delivery.

Purpose of the Study:

  • To enhance the dissolution behavior and bioavailability of fenbufen.
  • To investigate spherical crystallization as a method for improving fenbufen's physicochemical properties.

Main Methods:

  • Solubility studies of fenbufen in various solvents.
  • Spherical crystallization using a two-solvent system (tetrahydrofuran-demineralized water) with a bridging liquid (isopropyl acetate).
  • Dissolution studies of spherical fenbufen crystals under varying relative humidity conditions.

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Main Results:

  • A two-solvent system with a bridging liquid successfully produced spherical fenbufen crystals.
  • Spherical crystals demonstrated improved wettability and dissolution capacity compared to needle-shaped crystals.
  • Dissolution profiles of spherical crystals remained stable after one month of storage at different relative humidities.

Conclusions:

  • Spherical crystallization is an effective method for improving fenbufen's dissolution properties.
  • Enhanced wettability of spherical crystals leads to better dissolution.
  • The developed spherical crystallization process is reproducible and yields stable drug formulations.