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Chained vesicles in vascular endothelial cells.

T Kosawada¹, R Skalak, G W Schmid-Schönbein

¹Graduate School of Human Sensing and Functional Sensor Engineering, Yamagata University, Yonezawa, Japan.

Journal of Biomechanical Engineering

|October 26, 1999

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This study explores the mechanics of chained vesicles in blood vessels. We found stable shapes and how unfolding affects energy, offering insights into vascular transport.

Area of Science:

Biophysics
Cell Biology
Vascular Biology

Background:

Endothelial cells contain chained vesicles implicated in transport.
The mechanical properties of these vesicles are not well understood.

Purpose of the Study:

To investigate the formation mechanism and mechanical characteristics of vascular endothelial chained vesicles.
To model vesicle behavior using membrane bending strain energy analysis.

Main Methods:

Theoretical investigation based on membrane bending strain energy.
Computation of axisymmetric vesicle shapes assuming cytoplasmic layer-induced spontaneous curvature.
Analysis of bending strain energy and membrane tension.

Main Results:

Related Experiment Videos

Identified mechanically stable shapes for chained vesicles, including a cylindrical tube form.
Demonstrated that vesicle unfolding increases bending energy without significant membrane tension increase.
Revealed the role of spontaneous curvature from attached cytoplasmic layers.

Conclusions:

The study provides a theoretical framework for understanding chained vesicle mechanics.
Findings offer insights into the formation and behavior of these structures in endothelial transport.
Membrane bending energy is a key factor in determining vesicle shape and stability.