Jove
Visualize
Contact Us

Related Experiment Videos

Subharmonic backscattering from ultrasound contrast agents.

P M Shankar1, P D Krishna, V L Newhouse

  • 1Department of Electrical and Computer Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.

The Journal of the Acoustical Society of America
|October 26, 1999
PubMed
Summary

Subharmonic generation in ultrasound contrast agents requires a threshold pressure. This study establishes relationships between microbubble parameters and threshold pressure, finding optimal conditions for enhanced ultrasonic contrast imaging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On-fiber electrooptic modulator/switch.

Applied optics·2010
Same author

Use of two-dimensional phase-only filters and compounding for speckle reduction and edge detection in ultrasonic B-scan images.

Applied optics·2009
Same author

Pressure sensor that uses bent biconically tapered single-mode fibers.

Optics letters·2009
Same author

Spatial filtering in speckle.

Optics letters·2009
Same author

Speckle reduction in ultrasonic images through a maximum likelihood based adaptive filter.

Physics in medicine and biology·2006
Same author

Comments on 'The effect of logarithmic compression on the estimation of the Nakagami parameter for ultrasonic tissue characterization'.

Physics in medicine and biology·2006
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Medical Imaging

Background:

  • Enhancing ultrasonic contrast is crucial for accurate tissue perfusion estimation.
  • Subharmonic generation from microbubbles offers improved contrast over standard methods.
  • Understanding microbubble behavior under acoustic irradiation is key.

Purpose of the Study:

  • To establish the relationship between physical parameters of coated microbubbles and threshold pressure for subharmonic generation.
  • To explain the observed increase in resonance frequency using the concept of acoustic radius.
  • To predict and experimentally verify optimal conditions for subharmonic generation in ultrasound contrast agents.

Main Methods:

  • Analytical solutions to the modified RPNNP equation for coated microbubbles.

Related Experiment Videos

  • Introduction of the 'acoustic radius' concept to explain resonance frequency shifts.
  • Experimental verification of predicted threshold pressures and optimal frequencies.

    • Main Results:

    • Established a relationship between microbubble physical parameters and threshold pressure.
    • Explained resonance frequency increase with the acoustic radius concept.
    • Confirmed a minimum threshold pressure for subharmonic generation at twice the resonance frequency.
    • Demonstrated low threshold pressures for subharmonic generation in contrast agents.

    Conclusions:

    • Subharmonic generation in ultrasound contrast agents requires a threshold insonifying pressure.
    • Optimal subharmonic generation occurs when microspheres are insonated at twice their resonance frequency.
    • Low threshold pressures for subharmonic generation are valuable for ultrasonic contrast imaging.