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Related Experiment Videos

Subharmonic backscattering from ultrasound contrast agents.

P M Shankar1, P D Krishna, V L Newhouse

  • 1Department of Electrical and Computer Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.

The Journal of the Acoustical Society of America
|October 26, 1999
PubMed
Summary

Subharmonic generation in ultrasound contrast agents requires a threshold pressure. This study establishes relationships between microbubble parameters and threshold pressure, finding optimal conditions for enhanced ultrasonic contrast imaging.

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Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Medical Imaging

Background:

  • Enhancing ultrasonic contrast is crucial for accurate tissue perfusion estimation.
  • Subharmonic generation from microbubbles offers improved contrast over standard methods.
  • Understanding microbubble behavior under acoustic irradiation is key.

Purpose of the Study:

  • To establish the relationship between physical parameters of coated microbubbles and threshold pressure for subharmonic generation.
  • To explain the observed increase in resonance frequency using the concept of acoustic radius.
  • To predict and experimentally verify optimal conditions for subharmonic generation in ultrasound contrast agents.

Main Methods:

  • Analytical solutions to the modified RPNNP equation for coated microbubbles.

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  • Introduction of the 'acoustic radius' concept to explain resonance frequency shifts.
  • Experimental verification of predicted threshold pressures and optimal frequencies.

    • Main Results:

    • Established a relationship between microbubble physical parameters and threshold pressure.
    • Explained resonance frequency increase with the acoustic radius concept.
    • Confirmed a minimum threshold pressure for subharmonic generation at twice the resonance frequency.
    • Demonstrated low threshold pressures for subharmonic generation in contrast agents.

    Conclusions:

    • Subharmonic generation in ultrasound contrast agents requires a threshold insonifying pressure.
    • Optimal subharmonic generation occurs when microspheres are insonated at twice their resonance frequency.
    • Low threshold pressures for subharmonic generation are valuable for ultrasonic contrast imaging.