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Related Experiment Videos

[Lichen pemphigoid associated with developing hepatitis B in a child].

B Flageul1, F Hassan, L Pinquier

  • 1Service de Dermatologie, Hôpital Saint-Louis, Paris.

Annales De Dermatologie Et De Venereologie
|October 26, 1999
PubMed
Summary

This case report details a rare childhood autoimmune blistering disease, lichen planus pemphigoides, linked with active hepatitis B and a subsequent lichen planus relapse. The findings suggest lichen planus and lichen planus pemphigoides may be variants of the same condition.

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Area of Science:

  • Dermatology
  • Immunology
  • Hepatology

Background:

  • Lichen planus pemphigoides is a rare autoimmune blistering disease typically affecting adults, with only four pediatric cases previously reported.
  • This study presents a unique case in a child, notable for its association with evolving hepatitis B and a subsequent relapse of lichen planus.

Observation:

  • A 10-year-old boy presented with pruritic papular lichenoid lesions and blisters on a background of lichen planus and normal skin.
  • Histopathology and immunofluorescence confirmed lichen planus pemphigoides, revealing IgG and C3 deposits at the dermo-epidermal junction and circulating antibodies.
  • Laboratory tests indicated active hepatitis B infection (HBsAg positive).

Findings:

  • The patient achieved remission with dapsone and topical steroids but experienced a non-bullous lichen planus relapse after treatment cessation.

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  • Histology of the relapse showed typical lichen planus, with negative immunofluorescence studies.
  • The case suggests a potential link between lichen planus, lichen planus pemphigoides, and hepatitis B, possibly indicating they are disease variants.

    • Implications:

    • This case supports the hypothesis that lichen planus and lichen planus pemphigoides may represent variants of a single disease spectrum.
    • The association with hepatitis B in this pediatric case warrants further investigation into potential co-factors or triggers for these dermatoses.