[Effect on the whole alimentary starvation on DNA synthesis in cells precursors in human bone marrow]

The rate of DNA synthesis in cells precursors of the bone marrow of 15 psychic patients was studied by tritiated thymidine autoradiography during different periods of whole alimentary starvation (duration 28 days) which was used with the aim of therapy. It was shown that starvation induced rapid, "leap", "uneven" block of DNA synthesis and decrease in mitotic index. It was found that DNA synthesis block was marked with different degree in different marrow cells. It was supposed that DNA synthesis block occured mainly during G1--S period of interphase. During the initial period of refeeding, intensification of DNA synthesis, which preceded to sharp increase in mitotic index, was observed.