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Updated: Jul 22, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma
A M Jordan1, T H Khan, H M Osborn
1Department of Chemistry, University of Reading, Whiteknights, UK.
Bioorganic & Medicinal Chemistry
|October 26, 1999
Abstract:
A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.
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