Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains
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Updated: Oct 18, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
R C Buijsman1, J E Basten, C M Dreef-Tromp
1Leiden Institute of Chemistry, Gorlaeus Laboratories, The Netherlands.
Abstract:
The synthesis of three heparin analogues (i.e. compounds VI-VIII) having perphosphorylated thrombin binding domains (TBDs) is reported. These compounds were tested in vitro for their antithrombin III (ATIII)-mediated anti-Xa and antithrombin activities. Conjugates VI and VIII show a remarkable increase in antithrombin activity compared to the structurally related conjugates with persulfated TBDs (i.e. compounds IV and V), whereas compound VII displays a diminished activity.
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